OS X 10.0 to 10.3 Versions Cheetah, Puma, Jaguar, Panther: Macintosh OS X Acrobat instructions:
To make Acrobat Reader the default PDF viewing tool on OS X, follow these instructions:

1) Hold down the Control key and click on any PDF file.
2) Then choose "Open with..."
3) Select "Other." A dialogue box will come up that allows you to find an Application.
4) Choose "Acrobat 5.0"* or later and...
5) Check the box that says "Always open with."
6) Click on the "Open" button.
* Technically, the version of Acrobat has to be 5.05 or later for OS X. You can discover your exact version by opening Acrobat Reader, going to the help menu, and choosing "About Acrobat." The exact version will be in the top left corner of the resulting dialogue box that opens.
OS X 10.4 or later Versions Tiger & Leopard: Macintosh OS X Acrobat instructions:

To make Acrobat Reader the default PDF viewing tool on OS X, follow these instructions:
1) Hold down the Control key and click on any PDF file (or select a PDF file and choose "Get info..." from the file menu).
2) Then choose "Get Info..."
3) A dialogue box will come up that allows you to find an Application under the "Open with:" section. See image on left.
4) Choose "Acrobat Reader 5.0"* or later version and...
5) Click on the "Change All..." button.
* Technically, the version of Acrobat has to be 5.05 or later for OS X. You can discover your exact version by opening Acrobat Reader, going to the help menu, and choosing "About Acrobat." The exact version will be in the top left corner of the resulting dialogue box that opens.
Support document 071